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Handbook Of Systems Biology Concepts And Insights

Handbook of Systems Biology  Concepts and Insights PDF

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Author: Marian Walhout
Publisher: Academic Press
ISBN: 9780128100462
Size: 79.28 MB
Format: PDF
Category : Science
Languages : en
Pages : 552
View: 1248


This book provides an entry point into Systems Biology for researchers in genetics, molecular biology, cell biology, microbiology and biomedical science to understand the key concepts to expanding their work. Chapters organized around broader themes of Organelles and Organisms, Systems Properties of Biological Processes, Cellular Networks, and Systems Biology and Disease discuss the development of concepts, the current applications, and the future prospects. Emphasis is placed on concepts and insights into the multi-disciplinary nature of the field as well as the importance of systems biology in human biological research. Technology, being an extremely important aspect of scientific progress overall, and in the creation of new fields in particular, is discussed in 'boxes' within each chapter to relate to appropriate topics. 2013 Honorable Mention for Single Volume Reference in Science from the Association of American Publishers' PROSE Awards Emphasizes the interdisciplinary nature of systems biology with contributions from leaders in a variety of disciplines Includes the latest research developments in human and animal models to assist with translational research Presents biological and computational aspects of the science side-by-side to facilitate collaboration between computational and biological researchers

Handbook Of Systems Biology

Handbook of Systems Biology PDF

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Author: Marian Walhout
Publisher: Academic Press
ISBN: 012385945X
Size: 57.92 MB
Format: PDF, Docs
Category : Science
Languages : en
Pages : 552
View: 3201


This book provides an entry point into Systems Biology for researchers in genetics, molecular biology, cell biology, microbiology and biomedical science to understand the key concepts to expanding their work. Chapters organized around broader themes of Organelles and Organisms, Systems Properties of Biological Processes, Cellular Networks, and Systems Biology and Disease discuss the development of concepts, the current applications, and the future prospects. Emphasis is placed on concepts and insights into the multi-disciplinary nature of the field as well as the importance of systems biology in human biological research. Technology, being an extremely important aspect of scientific progress overall, and in the creation of new fields in particular, is discussed in 'boxes' within each chapter to relate to appropriate topics. 2013 Honorable Mention for Single Volume Reference in Science from the Association of American Publishers' PROSE Awards Emphasizes the interdisciplinary nature of systems biology with contributions from leaders in a variety of disciplines Includes the latest research developments in human and animal models to assist with translational research Presents biological and computational aspects of the science side-by-side to facilitate collaboration between computational and biological researchers

Handbook Of Research On Systems Biology Applications In Medicine

Handbook of Research on Systems Biology Applications in Medicine PDF

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Author: Daskalaki, Andriani
Publisher: IGI Global
ISBN: 1605660779
Size: 38.63 MB
Format: PDF, ePub, Docs
Category : Technology & Engineering
Languages : en
Pages : 982
View: 4046


"This book highlights the use of systems approaches including genomic, cellular, proteomic, metabolomic, bioinformatics, molecular, and biochemical, to address fundamental questions in complex diseases like cancer diabetes but also in ageing"--Provided by publisher.

Handbook Of Computational Biology Second Edition

Handbook of Computational Biology  Second Edition PDF

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Author: Srinivas Aluru
Publisher: Chapman and Hall/CRC
ISBN: 9781439874097
Size: 11.82 MB
Format: PDF
Category : Mathematics
Languages : en
Pages : 2406
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Now available as a three-volume set, the second edition of this popular handbook provides expanded coverage of many important topics and recent developments in computational biology. With updates in each chapter, the book incorporates the latest research and applications in systems biology, including next-generation sequencing. The three volumes focus on Computational Genomics, Computational Systems Biology, and Computational Structural Biology.

Handbook Of Statistical Systems Biology

Handbook of Statistical Systems Biology PDF

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Author: Michael Stumpf
Publisher: John Wiley & Sons
ISBN: 1119952042
Size: 39.35 MB
Format: PDF, Mobi
Category : Science
Languages : en
Pages : 530
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Systems Biology is now entering a mature phase in which the key issues are characterising uncertainty and stochastic effects in mathematical models of biological systems. The area is moving towards a full statistical analysis and probabilistic reasoning over the inferences that can be made from mathematical models. This handbook presents a comprehensive guide to the discipline for practitioners and educators, in providing a full and detailed treatment of these important and emerging subjects. Leading experts in systems biology and statistics have come together to provide insight in to the major ideas in the field, and in particular methods of specifying and fitting models, and estimating the unknown parameters. This book: Provides a comprehensive account of inference techniques in systems biology. Introduces classical and Bayesian statistical methods for complex systems. Explores networks and graphical modeling as well as a wide range of statistical models for dynamical systems. Discusses various applications for statistical systems biology, such as gene regulation and signal transduction. Features statistical data analysis on numerous technologies, including metabolic and transcriptomic technologies. Presents an in-depth presentation of reverse engineering approaches. Provides colour illustrations to explain key concepts. This handbook will be a key resource for researchers practising systems biology, and those requiring a comprehensive overview of this important field.

Molecular Biology Das Original Mit Bersetzungshilfen

Molecular Biology  Das Original mit   bersetzungshilfen PDF

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Author: David P. Clark
Publisher: Spektrum Akademischer Verlag
ISBN: 9783827416964
Size: 41.96 MB
Format: PDF, Kindle
Category : Science
Languages : en
Pages : 808
View: 3788


Easy Reading: Diese neue Lehrbuch-Reihe bietet erstklassige englischsprachige Original-Lehrbücher mit deutschen Übersetzungshilfen. Molecular biology is a fast-growing field. Students need a clear understanding of new discoveries and laboratory methods, as well as a firm grasp of the fundamental concepts. Clark's Molecular Biology offers both.

Wissenschaft Und Kunst Der Modellierung

Wissenschaft und Kunst der Modellierung PDF

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Author: Bernhard Thalheim
Publisher: Walter de Gruyter GmbH & Co KG
ISBN: 1501501259
Size: 77.91 MB
Format: PDF, ePub
Category : Philosophy
Languages : de
Pages : 641
View: 3276


Models are one of the main instruments in scientific research. Disciplines have developed a different understanding of the notion, function and purpose of models. We thus need a systematic approach in order to understand, to build and to use models. This book gives an insight into the disciplinary modelling know-how and is a starting point to develop a general model approach that generalises and combines for an interdisciplinary use.

Synthetic Biology Handbook

Synthetic Biology Handbook PDF

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Author: Darren N. Nesbeth
Publisher: CRC Press
ISBN: 1466568488
Size: 37.61 MB
Format: PDF, ePub, Docs
Category : Medical
Languages : en
Pages : 318
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The Synthetic Biology Handbook explains the major goals of the field of synthetic biology and presents the technical details of the latest advances made in achieving those goals. Offering a comprehensive overview of the current areas of focus in synthetic biology, this handbook: Explores the standardisation of classic molecular bioscience approaches Addresses the societal context and potential impacts of synthetic biology Discusses the use of legacy systems as tools for new product development Examines the design and construction of de novo cells and genetic codes Describes computational methods for designing genes and gene networks Thus, the Synthetic Biology Handbook provides an accurate sense of the scope of synthetic biology today. The handbook also affords readers with an opportunity to scrutinize the underlying science and decide for themselves what aspects of synthetic biology are most valuable to their research and practice.

Computational Methods In Systems Biology

Computational Methods in Systems Biology PDF

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Author: Jérôme Feret
Publisher: Springer
ISBN: 3319674714
Size: 14.20 MB
Format: PDF, ePub, Mobi
Category : Computers
Languages : en
Pages : 332
View: 5218


This book constitutes the refereed proceedings of the 15th International Conference on Computational Methods in Systems Biology, CMSB 2017, held in Darmstadt, Germany, in September 2017. The 15 full papers, 4 tool papers and 4 posters presented together with 1 invited talk were carefully reviewed and selected from 41 regular paper submissions. Topics of interest include formalisms for modeling biological processes; models and their biological applications; frameworks for model verication, validation, analysis, and simulation of biological systems; high-performance computational systems biology and parallel implementations; model inference from experimental data; model integration from biological databases; multi-scale modeling and analysis methods; and computational approaches for synthetic biology.

An Introduction To Computational Systems Biology

An Introduction to Computational Systems Biology PDF

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Author: Karthik Raman
Publisher: CRC Press
ISBN: 0429944527
Size: 64.20 MB
Format: PDF, ePub
Category : Computers
Languages : en
Pages : 358
View: 1935


This book delivers a comprehensive and insightful account of applying mathematical modelling approaches to very large biological systems and networks—a fundamental aspect of computational systems biology. The book covers key modelling paradigms in detail, while at the same time retaining a simplicity that will appeal to those from less quantitative fields. Key Features: A hands-on approach to modelling Covers a broad spectrum of modelling, from static networks to dynamic models and constraint-based models Thoughtful exercises to test and enable understanding of concepts State-of-the-art chapters on exciting new developments, like community modelling and biological circuit design Emphasis on coding and software tools for systems biology Companion website featuring lecture videos, figure slides, codes, supplementary exercises, further reading, and appendices: https://ramanlab.github.io/SysBioBook/ An Introduction to Computational Systems Biology: Systems-Level Modelling of Cellular Networks is highly multi-disciplinary and will appeal to biologists, engineers, computer scientists, mathematicians and others.

Hybrid Systems Biology

Hybrid Systems Biology PDF

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Author: Eugenio Cinquemani
Publisher: Springer
ISBN: 3319471511
Size: 49.52 MB
Format: PDF, Mobi
Category : Computers
Languages : en
Pages : 179
View: 7609


This book constitutes the refereed proceedings of the 5th International Workshop on Hybrid Systems Biology, HSB 2016, held in Grenoble, France, in October 2016. The 11 full papers presented in this book were carefully reviewed and selected from 26 submissions. They were organized and presented in 4 thematic sessions also reflected in this book: model simulation; model analysis; discrete and network modelling; stochastic modelling for biological systems.

Case Studies In Systems Biology

Case Studies in Systems Biology PDF

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Author: Pavel Kraikivski
Publisher: Springer Nature
ISBN: 3030677427
Size: 69.34 MB
Format: PDF, Mobi
Category :
Languages : en
Pages :
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Handbook Of Natural Computing

Handbook of Natural Computing PDF

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Author: Grzegorz Rozenberg
Publisher: Springer
ISBN: 9783540929116
Size: 33.58 MB
Format: PDF
Category : Computers
Languages : en
Pages : 2052
View: 3416


Natural Computing is the field of research that investigates both human-designed computing inspired by nature and computing taking place in nature, i.e., it investigates models and computational techniques inspired by nature and also it investigates phenomena taking place in nature in terms of information processing. Examples of the first strand of research covered by the handbook include neural computation inspired by the functioning of the brain; evolutionary computation inspired by Darwinian evolution of species; cellular automata inspired by intercellular communication; swarm intelligence inspired by the behavior of groups of organisms; artificial immune systems inspired by the natural immune system; artificial life systems inspired by the properties of natural life in general; membrane computing inspired by the compartmentalized ways in which cells process information; and amorphous computing inspired by morphogenesis. Other examples of natural-computing paradigms are molecular computing and quantum computing, where the goal is to replace traditional electronic hardware, e.g., by bioware in molecular computing. In molecular computing, data are encoded as biomolecules and then molecular biology tools are used to transform the data, thus performing computations. In quantum computing, one exploits quantum-mechanical phenomena to perform computations and secure communications more efficiently than classical physics and, hence, traditional hardware allows. The second strand of research covered by the handbook, computation taking place in nature, is represented by investigations into, among others, the computational nature of self-assembly, which lies at the core of nanoscience, the computational nature of developmental processes, the computational nature of biochemical reactions, the computational nature of bacterial communication, the computational nature of brain processes, and the systems biology approach to bionetworks where cellular processes are treated in terms of communication and interaction, and, hence, in terms of computation. We are now witnessing exciting interaction between computer science and the natural sciences. While the natural sciences are rapidly absorbing notions, techniques and methodologies intrinsic to information processing, computer science is adapting and extending its traditional notion of computation, and computational techniques, to account for computation taking place in nature around us. Natural Computing is an important catalyst for this two-way interaction, and this handbook is a major record of this important development.

Systems Biology Of Stress In Bacillus Megaterium And Its Potential Applications

Systems biology of stress in Bacillus megaterium and its potential applications PDF

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Author: Thibault Godard
Publisher: Cuvillier Verlag
ISBN: 3736983360
Size: 40.23 MB
Format: PDF, ePub, Mobi
Category : Technology & Engineering
Languages : en
Pages : 236
View: 1193


Generally, once a producer has been genetically designed, optimal process parameters are established to maximise its potential for industrial production. Despite this upstream work, bacterial cells are constantly exposed to various kinds of stress during the whole production process, including e.g. mechanical induced stress, high nutrient or product concentrations and variations of temperature, medium composition or oxygen availability. In this context, the main objective of this work was to investigate more deeply the impact of harsh cultivation temperatures (between 15 and 45°C) and osmotic stress (mimicked using up to 1.8 M NaCl) on the metabolism of the wild-type B. megaterium DSM319 during unlimited growth. To this end, a holistic study including transcriptome, proteome, metabolome and fluxome analyses was performed to offer an integrated picture of cellular adaptation and to find underlying genetic targets for the development of more robust production hosts. Interestingly, while both stress conditions resulted in disruption of redox balance, decreased biomass yields and reduced substrate uptake rates, the flux distribution within the central carbon and energy metabolism as well as the levels of the corresponding mRNAs and proteins were only locally affected. On the contrary, significant modulation of metabolite pools was observed and might constitute a key mechanism to compensate for loss of enzyme activity and maintain or adjust metabolic fluxes under stressful conditions. In addition, specific responses occurring at every biological level were detected in both cases. In particular, exposure at high and low temperature triggered the production of so-called heat and cold shock proteins, respectively, whose functions support sustained growth under these adverse conditions. Under ionic osmotic stress, on the other hand, the whole metabolic machinery was reorganised towards production of the osmoprotectant proline using an alternative pathway only active under this condition. More surprisingly, although B. megaterium has long been known for its capacity to produce the biopolymer polyhydroxybutyric acid (PHB), a positive correlation between intracellular PHB content and salt concentration could be demonstrated for the first time. As neither the concentration of the enzymes involved in the classical PHB-pathway nor that of their related mRNAs significantly increased, these proteins were systematically overproduced in new plasmid strains, resulting in an up to 75 % higher PHB content. Finally, in silico modelling using elementary flux mode analysis was applied and highlighted new genetic targets for the further improvement of PHB production in B. megaterium.

Network Medicine

Network Medicine PDF

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Author: Joseph Loscalzo
Publisher: Harvard University Press
ISBN: 0674545524
Size: 72.43 MB
Format: PDF, ePub, Docs
Category : Medical
Languages : en
Pages : 500
View: 146


Big data, genomics, and quantitative approaches to network-based analysis are combining to advance the frontiers of medicine as never before. With contributions from leading experts, Network Medicine introduces this rapidly evolving field of research, which promises to revolutionize the diagnosis and treatment of human diseases.

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